Cancer Biology Concentration

mouse tissue after radiation
Mammary tissue from a mouse withPten conditionally deleted in stromal fibroblasts exhibiting labuloalveolarhyperplasia after a single dose of radiation.  From Sizemore et al, Nat.Comm.  17;9(1):2783 2018. PMID: 30018330

The Cancer Biology Program, an interdisciplinary program leading to a Ph.D. degree, was established in 2001 to provide students with training in a variety of areas of cancer biology research. Cancer is a multi-step disease resulting from a series of genetic and epigenetic changes that abrogate normal cellular controls. The goal of the program is to provide a framework in which to develop the necessary skills needed to becoming an independent investigator in the field of cancer biology. 

The Cancer Biology Program is composed of MUSC faculty whose interests include basic studies in molecular biology, biochemistry, genetics, cell biology and immunology and those whose translational research is focused on problems of immediate clinical applicability. The Cancer Biology curriculum provides an overview of cancer biology and allows students the opportunity to pursue research under faculty mentors who conduct research relevant to understanding the molecular or cellular basis of any aspect of the cause, characteristics and treatment of cancer. Thus, the Cancer Biology Program provides research opportunities in many areas of Cancer Biology including Functional Genetics, Molecular Biology of Cancer, Experimental Therapeutics and Cancer Immunology. Students are encouraged to use the resources and expertise of several laboratories during the development of their cancer related dissertation projects, providing an enhanced experience that increases the expertise and competitiveness of our graduates. Following training in the first year common curriculum students are able to take additional coursework, participate in both formal seminar presentations and journal clubs to hone scientific knowledge and methodologies. Successful students complete a publishable research project under a faculty mentor and present the research as a thesis.

The Cancer Biology Program has faculty with divergent research areas including:

  • Apoptosis
  • Angiogenesis
  • Migration and Invasion
  • Metastasis Tumor
  • Microenvironment
  • Molecular Profiling
  • Immunotherapy
  • Small Molecule Intervention and Drug Discovery

Cancer Biology Faculty