Proteins in Heart Disease (Cardiovascular Proteomics)
About This Research Area
The Cardiovascular Proteomics group provides trainees exposure to new technologies for proteomic analysis and helps our fellows apply such approaches to generate discoveries in specific areas of cardiovascular research. Our faculty are using proteomic analysis to study the basic underlying mechanisms of congestive heart failure, extracellular matrix remodeling events in heart development and disease, proteomic analysis of cardiovascular disease risk and several new technologies for proteomic assessment of heart disease. One of our current trainees is developing proteomic methods to study diastolic dysfunction. Work on his and other projects is being initiated using a synergistic combination of contemporary two-dimensional gel electrophoresis in a new high throughput facility, a well-established mass spectrometry facility, and state-of-the-art methods of biological systems analysis.
Scott W. Argraves, Ph.D.
Extracellular Matrix Biology
John M. Arthur, M.D., Ph.D.
Discovery of Disease Biomarkers Using Proteomic and Informatic Technologies
John Baatz, Ph.D.
Characterization of Hemoglobin and Surfactant Protein in Distal Airway Cells
Lauren Ball, Ph.D.
Michael G. Janech, Ph.D.
Identification of Urine Protein Markers of Glomerular Disease
Edward Krug, Ph.D.
Assessing the Anatomical Proteome of Heart Morphogenesis
Roger R. Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease
Michael R. Zile, M.D.
Diastolic Heart Failure and Growth Regulation