Proteins in Heart Disease (Cardiovascular Proteomics)

About This Research Area

The Cardiovascular Proteomics group provides trainees exposure to new technologies for proteomic analysis and helps our fellows apply such approaches to generate discoveries in specific areas of cardiovascular research. Our faculty are using proteomic analysis to study the basic underlying mechanisms of congestive heart failure, extracellular matrix remodeling events in heart development and disease, proteomic analysis of cardiovascular disease risk and several new technologies for proteomic assessment of heart disease. One of our current trainees is developing proteomic methods to study diastolic dysfunction. Work on his and other projects is being initiated using a synergistic combination of contemporary two-dimensional gel electrophoresis in a new high throughput facility, a well-established mass spectrometry facility, and state-of-the-art methods of biological systems analysis.

Research Faculty

Scott W. Argraves, Ph.D.
Extracellular Matrix Biology

John M. Arthur, M.D., Ph.D.
Discovery of Disease Biomarkers Using Proteomic and Informatic Technologies

John Baatz, Ph.D.
Characterization of Hemoglobin and Surfactant Protein in Distal Airway Cells

Lauren Ball, Ph.D.
Proteomics

Michael G. Janech, Ph.D.
Identification of Urine Protein Markers of Glomerular Disease

Edward Krug, Ph.D.
Assessing the Anatomical Proteome of Heart Morphogenesis

Roger R. Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease

Michael R. Zile, M.D.
Diastolic Heart Failure and Growth Regulation