Molecular Basis of Cardiovascular Disease
About This Research Area
This inherently multidisciplinary research field is designed to provide our trainees with the knowledge base, technical abilities, problem solving skills and research experience necessary to find bold new approaches to aid understanding, diagnosis and treatment of heart disease. Areas of research interest in this program include regulation of cardiac growth, regulation of cardiovascular function and metabolism, regulation of muscle contraction and protein turnover, and signal transduction pathways and transcriptional regulation in healthy and diseased myocardium.
Numerous model systems are used by our faculty, including molecular and whole organ physiological approaches focused on transgenic and knock out animal models, surgical models of cardiovascular disease, as well as state-of-the-art analyses of isolated adult cardiac myocytes in vitro. These exciting studies are leading to the identification of novel therapeutic targets for the treatment of cardiovascular disease.
Kelley Argraves, Ph.D.
Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis
John M. Arthur, M.D., Ph.D.
Discovery of Disease Biomarkers Using Proteomic and Informatic Technologies
Lauren E. Ball, Ph.D.
Insulin Receptor and (IGF-1) Receptor Signaling Pathways
Craig Beeson, Ph.D.
Regulation of Cardiac Bioenergetics during Stress Responses
Joe Blumer, Ph.D.
Role of GPR Proteins in Mammalian Cell Division and the Immune System
Amy Bradshaw, Ph.D.
Collagen Deposition in Cardiac Hypertrophy
George Cooper, IV, M.D.
Structure-Function Relationships of the Cardiac Extramyofilament Cytoskeleton
Brent M. Egan, M.D.
Obesity, Oxidative Stress and Cardiovascular Risk
Samar Hammad, Ph.D.
Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages
Brett Harris, Ph.D.
The Development of the Atrio-ventricular Conduction System
John S. Ikonomidis, M.D., Ph.D.
Extracellular Matrix Remodeling in Thoracic Aortic Aneurysm Disease
Edward Krug, Ph.D.
Assessing the Anatomical Proteome of Heart Morphogenesis
Steven W. Kubalak, Ph.D.
Signaling Mechanisms Regulating Cardiac Remodeling
Dhandapani Kuppuswamy, Ph.D.
Growth and Protection of Hypertrophing Myocardium
Amanda LaRue, Ph.D.
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors
Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development
Louis Lutrell, M.D., Ph.D.
G Protein-coupled Receptor Signaling in the Cardiovascular System
Roger Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease
Paul J. McDermott, Ph.D.
Translational Regulation of Cardiac Protein Synthesis
Donald R. Menick, Ph.D.
Regulation of Gene Expression in Cardiac Myocytes
Suniti Misra, Ph.D.
Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis
Terrence X. O'Brien, M.D.
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System
Arno Wessels, Ph.D.
Mechanisms of Cardiac Morphogenesis
Michael R. Zile, M.D.
Diastolic Heart Failure and Growth Regulation