Molecular Basis of Cardiovascular Disease

About This Research Area

This inherently multidisciplinary research field is designed to provide our trainees with the knowledge base, technical abilities, problem solving skills and research experience necessary to find bold new approaches to aid understanding, diagnosis and treatment of heart disease. Areas of research interest in this program include regulation of cardiac growth, regulation of cardiovascular function and metabolism, regulation of muscle contraction and protein turnover, and signal transduction pathways and transcriptional regulation in healthy and diseased myocardium.

Numerous model systems are used by our faculty, including molecular and whole organ physiological approaches focused on transgenic and knock out animal models, surgical models of cardiovascular disease, as well as state-of-the-art analyses of isolated adult cardiac myocytes in vitro. These exciting studies are leading to the identification of novel therapeutic targets for the treatment of cardiovascular disease.

Research Faculty

Kelley Argraves, Ph.D.
Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis

John M. Arthur, M.D., Ph.D.
Discovery of Disease Biomarkers Using Proteomic and Informatic Technologies

Lauren E. Ball, Ph.D.
Insulin Receptor and (IGF-1) Receptor Signaling Pathways

Craig Beeson, Ph.D.
Regulation of Cardiac Bioenergetics during Stress Responses

Joe Blumer, Ph.D.
Role of GPR Proteins in Mammalian Cell Division and the Immune System

Amy Bradshaw, Ph.D.
Collagen Deposition in Cardiac Hypertrophy

George Cooper, IV, M.D.
Structure-Function Relationships of the Cardiac Extramyofilament Cytoskeleton

Brent M. Egan, M.D.
Obesity, Oxidative Stress and Cardiovascular Risk

Samar Hammad, Ph.D.
Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages

Brett Harris, Ph.D.
The Development of the Atrio-ventricular Conduction System

John S. Ikonomidis, M.D., Ph.D.
Extracellular Matrix Remodeling in Thoracic Aortic Aneurysm Disease

Edward Krug, Ph.D.
Assessing the Anatomical Proteome of Heart Morphogenesis

Steven W. Kubalak, Ph.D.
Signaling Mechanisms Regulating Cardiac Remodeling

Dhandapani Kuppuswamy, Ph.D.
Growth and Protection of Hypertrophing Myocardium

Amanda LaRue, Ph.D.
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors

Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development

Louis Lutrell, M.D., Ph.D.
G Protein-coupled Receptor Signaling in the Cardiovascular System

Roger Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease

Paul J. McDermott, Ph.D.
Translational Regulation of Cardiac Protein Synthesis

Donald R. Menick, Ph.D.
Regulation of Gene Expression in Cardiac Myocytes

Suniti Misra, Ph.D.
Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis

Terrence X. O'Brien, M.D.
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System

Arno Wessels, Ph.D.
Mechanisms of Cardiac Morphogenesis

Michael R. Zile, M.D.
Diastolic Heart Failure and Growth Regulation