Cell Signaling in Cardiovascular Disease
About This Research Area
Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how cells transduce intracellular responses prompted by such signals. In addition to endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Understanding of cell signaling processes is fundamental to all areas of cardiovascular research. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining aberrant signaling mechanisms associated with cardiovascular disease. Significantly, many of the recent breakthroughs in cardiovascular therapeutics result from basic studies on signaling molecules.
Kelley Argraves, Ph.D.
Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis
Scott W. Argraves, Ph.D.
Extracellular Matrix Biology
John Baatz, Ph.D.
Characterization of Hemoglobin and Surfactant Protein in Distal Airway Cells
Craig Beeson, Ph.D.
Regulation of Cardiac Bioenergetics during Stress Responses
Maria Buse, M.D., Ph.D.
Diabetes: Mechanisms of Insulin Resistance
James A. Cook, Ph.D.
Signal Transduction Pathways in Shock
Samar Hammad, Ph.D.
Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages
Brett Harris, Ph.D.
The Development of the Atrio-ventricular Conduction System
Steven W. Kubalak, Ph.D.
Signaling Mechanisms Regulating Cardiac Remodeling
Dhandapani Kuppuswamy, Ph.D.
Growth and Protection of Hypertrophing Myocardium
Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development
Louis Luttrell, M.D., Ph.D.
G Protein-coupled Receptor Signaling in the Cardiovascular System
Paul J. McDermott, Ph.D.
Translational Regulation of Cardiac Protein Synthesis
Donald R. Menick, Ph.D.
Regulation of Gene Expression in Cardiac Myocytes
Suniti Misra, Ph.D.
Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis
Terrence X. O'Brien, M.D.
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System
Rick Schnellmann, Ph.D.
Elucidation of Signaling Pathways of Cell Injury, Death and Regeneration
Steve Tomlinson, Ph.D.
The Complement System and Vascular Inflammation
Bryan Toole, Ph.D.
Functions of Hyaluronan and Emmprin in Oncogenic, Inflammatory and Atherosclerotic Signaling Pathways