Cardiac Stem Cells & Regenerative Medicine

About This Research Area

Regenerative medicine is an emerging field that intersects both basic science and clinical research. This research is focused on the regeneration and remodeling of tissue and organs for the purpose of repairing, replacing, maintaining, or enhancing cardiac function, as well as the engineering and growing functional tissue substitutes in vitro for implantation in vivo as a biological replacement for damaged or diseased myocardium. Areas of work in cardiac tissue engineering include cell seeding on solid biodegradable scaffolds, embedding and casting in 3D hydrogels, and technologies based on principles of tissue self-assembly (cell sheet technology, magnetic force-based tissue engineering). The studies use neonatal cardiomyocytes, as well as initiating the examination of the utility of stem cell lines as potential resources for regeneration of new myocytes for bioengineered cardiac tissue. Other studies include using mice with genetically labeled cells to trace bone marrow stem cell mobilization and recruitment into heart valve tissue.

Research Faculty

George Cooper, IV, M.D.
Structure-Function Relationships of the Cardiac Extramyofilament Cytoskeleton

Dhandapani Kuppuswamy, Ph.D.
Growth and Protection of Hypertrophing Myocardium

Amanda LaRue, Ph.D.
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors

Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development

Roger R. Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease

Paul J. McDermott, Ph.D.
Translational Regulation of Cardiac Protein Synthesis

Rick Visconti, Ph.D.
Role of Adult Bone Marrow Stem Cells in Cardiac Tissue Homeostasis and Injury-repair

Michael R. Zile, M.D.
Diastolic Heart Failure and Growth Regulation